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. 2021 Apr 19;23(6):468. doi: 10.3892/mmr.2021.12107

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — HPostC promotes H3K14 hyperacetylation at the miR-30a gene promoter via the downregulation of HDAC2 in senescent cardiomyocytes. (A) The mRNA expression of miR-30a-5p in senescent cardiomyocytes after treatment with TSA. (B and C) The enrichment of H3K14 acetylation at miR-30a-5p gene promoter was identified by ChIP-PCR analysis in the senescent cardiomyocytes. (D and E) The HDAC2 mRNA and protein expression levels in senescent cardiomyocytes. (F and G) HDAC2 binding at the miR-30a-5p gene promoter was analyzed by ChIP-PCR in senescent cardiomyocytes. Data are presented as the mean ± SD from three independent experiments. *P<0.05, **P<0.01. HPostC, hypoxia postconditioning; miR, microRNA; TSA, trichostatin A; HDAC2, histone deacetylase 2; ChIP, chromatin immunoprecipitation; H/R, hypoxia/reoxygenation.