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. 2021 Apr 20;23(6):470. doi: 10.3892/mmr.2021.12109

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Copyright: © Wei et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Role of circ_0058357 knockdown on tumor growth of NSCLC cells in vivo. (A) A549 cells were transfected with shRNA NC and circ_0058357 shRNA. Tumor size was detected once a week for consecutive 6 weeks. Then, a tumor growth curve was generated according to the tumor volume at different time points. (B) After injection for 7 weeks, tumors in different group were removed and imaged. (C) Quantitative analysis of tumor weight in the three groups, (n=8/each group). (D) Ki67 expression in tumor tissues was determined via immunohistochemistry staining. (D) The positive rate of Ki67 in tumor tissues was assessed using Image Pro Plus software. **P<0.01. NC, negative control; shRNA, short hairpin RNA; circ, circular RNA.