Figure 3.

Overexpression of miR-146a inhibited neuroinflammatory response in hippocampus of LPS-induced mice. (A) The relative expression of iNOS, IL-1β, TNF-α; (B) The relative expression of IRAK1, TRAF6, p-NF-κB p65/ NF-κB p65. *P<0.05 and **P<0.01 vs. control group; ^#P<0.05 and ^##P<0.01 vs. LPS group; ^&&P<0.01 vs. mimic-NC group; ^%%P<0.01 vs. siRNA-NC group. miR, microRNA; LPS, lipopolysaccharide; NC, negative control; si, short interfering; iNOS, inducible nitric oxide synthase; IRAK1, recombinant interleukin 1 receptor-associated kinase 1; TRAF6, TNF receptor-associated factor 6; p-, phosphorylated.