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. 2021 May 5;21:249. doi: 10.1186/s12935-021-01953-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — RAD51 confers ovarian cancer dependency. a Using the Open Targets platform, target-disease associations of RAD51 were calculated, and those scoring higher than 0.5 were depicted. b Fitness score is a quantitative evaluation of the cell viability effect elicited by CRISPR–Cas9-mediated cell inactivation. In Project Score Database, the fitness scores of RAD51 in 30 ovarian cancer cell lines were explored. c Integrated analysis of RAD51 expression in 17 datasets using Oncomine