Table 1.
Characteristics of study cohort 1 and baseline statistics of CSF measurements
| Cohort 1 | |||
|---|---|---|---|
| DC (n = 72) | AD (n = 54) | p-value AD - DC | |
| Age | 69.71 ± 10.68 | 72.76 ± 10.91 | 0.1184* |
| Gender | 0.0057$ | ||
| Women | 35 (48.6%) | 40 (74.1%) | |
| Men | 37 (51.2%) | 14 (25.9%) | |
| CSF GPNMB [pg/ml] | 9806 ± 4006 | 11270 ± 4957 | 0.0788# |
| APOE genotype | |||
| ε2/ε2 | – | 1 | |
| ε2/ε3 | 10 | 4 | |
| ε2/ε4 | 2 | 3 | |
| ε3/ε3 | 44 | 12 | |
| ε3/ε4 | 15 | 29 | |
| ε4/ε4 | 1 | 5 | |
| ≥ 1 APOE ε4 allele, n (%) | 18 (25%) | 37 (68.5%) | < 0.0001$ |
| CSF p-Tau [pg/ml]* | 47.47 ± 18.89 | 111.5 ± 46.66 | < 0.0001# |
| CSF t-Tau [pg/ml]* | 257.1 ± 91.43 | 760.2 ± 310.2§ | < 0.0001# |
| CSF Aβ38 [pg/ml]* | 2271 ± 997.3 | 2543 ± 889.4 | 0.0902# |
| CSF Aβ40 [pg/ml]* | 6871 ± 3050 | 7614 ± 2875 | 0.1843# |
| CSF Aβ42 [pg/ml]* | 709.2 ± 394 | 359.7 ± 141.6 | < 0.0001# |
| CSF Aβ 42/40* | 0.0994 ± 0.0231 | 0.0478 ± 0.0104 | < 0.0001* |
The indicated parameters had been determined and partially reported before in a previous study [31]. §Some samples (20%) exceeded the upper limit of detection of the assay and were set to 1200 pg/ml. *Unpaired t-test, #Mann-Whitney test, or $Fisher’s exact test for differences between the diagnostic groups