Table 5.
Known checkpoints examined for expression and survival in MPM
| Gene | Alternative names | Altered expressiona (mRNA) | OSb (mRNA) | Comments |
|---|---|---|---|---|
| CD244 | 2B4 | No | No | |
| TNFRSF9 | 4-1BB | No | No | |
| ANGPTL7 | CDT6 | No | No | |
| CD80 | B7-1 | No | No | |
| CD86 | B7-2 | No | No | |
| ICOSLG | B7-H2 | No | No | |
| CD276 | B7-H3 | N/A |
Yes (p = 0.039) |
High expression associated with poor OS |
| VTCN1 | B7-H4 | No | No | |
| HHLA2 | B7-H5 | No | No | |
| NCR3LG1 | B7-H6 | N/A | Not found in UALCAN | |
| BTLA | N/A | No | ||
| BTN1A1 | BTN | No | No | |
| BTN3A1 | CD277 |
Yes (p = 0.029) |
Yes (p = 0.0093) |
Upregulated in MPM High expression associated with better OS |
| BTN3A3 | BTF3 |
Yes (p = 0.042) |
Yes (p = 0.0065) |
Upregulated in MPM High expression associated with better OS |
| PVR | CD155 | No |
Yes (p = 0.023) |
High expression associated with poor OS |
| CD160 | BY55 | No | No | |
| LY9 | CD229 | No | No | |
| CD28 | Tp44 | No | No | |
| TNFRSF8 | CD30 | No | No | |
| CD40 | TNFRSF5 | No | No | |
| CD47 | MER6, IAP |
Yes (p = 0.012) |
No | Upregulated in MPM |
| CD48 | BLAST1 | No | No | |
| CD84 | SLAMF5 | No |
Yes (p = 0.042) |
High expression associated with poor OS |
| CD96 | TACTILE | No | No | |
| CTLA-4 | CD152 | No | No | |
| CD226 | DNAM-1 | No | No | |
| LGALS9 | Galectin-9 | No | No | |
| TNFRSF18 | GITR | N/A | No | |
| TNFRSF14 | HVEM | No |
Yes (p = 0.019) |
High expression associated with better OS |
| TIM3 | HAVCR2 | No | No | |
| ICOS | AILIM | No | No | |
| LAG3 | CD223 |
Yes (p = 0.011) |
Yes (p = 0.021) |
Upregulated in MPM High expression associated with better OS |
| LAIR-1 | No | No | ||
| LAIR-2 | CD306 | No | No | |
| LILRA2 | LIR7, CD85H | No |
Yes (p = 0.038) |
High expression associated with better OS |
| LILRA3 | LIR4, CD85E | No | No | |
| LILRA5 | LIR9, CD85F | No | No | |
| LILRB1 | LIR1, CD85 | No | No | |
| LILRB2 | LIR2, CD85D | No | No | |
| LILRB3 | LIR3, CD85A | No | No | |
| LILRB4 | LIR5, CD85K | No | No | |
| LILRB5 | LIR8, CD85C | No | No | |
| Nectin-1 | PVRL1 | No |
Yes (p = 0.0042) |
High expression associated with poor OS |
| Nectin-2 | PVRL2 | No | No | |
| Nectin-3 | PVRL3 |
Yes (p = 0.012) |
Yes (p = 0.024) |
Upregulated in MPM High expression associated with poor OS |
| NCR3 | NKp30 | No | No | |
| SLAMF6 | NTB-A | N/A | No | |
| OX40 | TNFRSF4 | No | No | |
| OX40L | TNFSF4 |
Yes (p = 0.047) |
Yes (p = 0.00018) |
High expression associated with poor OS |
| PD1 | CD279 | No | No | |
| PD-L1 | CD274 | N/A | No | |
| PD-L2 | B7DC | No | No | |
| PVRIG | CD112R | No | No | |
| SIRPA | PTPNS1 | No |
Yes (p = 0.0091) |
High expression associated with better OS |
| SIRPG | SIRP gamma | No | No | |
| SIRPB1 | SIRP-beta 1 |
Yes (p = 7.92 × 10–7) |
No | Upregulated in MPM |
| SIRPB2 | N/A | No | ||
| SLAMF1 | CD150 | No | No | |
| SLAMF7 | CD319 | No | No | |
| TIGIT | N/A | No | ||
| VISTA | VSIR, C10ORF54 | N/A |
Yes (p = 0.00093) |
High expression associated with better OS |
| VSIG3 | IGSF11 | N/A | No | Ligand of VISTA |
| VSIG4 | CRIG | No | No |