Table 2.
Intra-and inter-individual variation of parameters of glucose metabolism during two different MMTTs
| Variables | MMTT-comparison of one meal three times | MMTT-comparison of two different meals | ||||||
|---|---|---|---|---|---|---|---|---|
| iAUC | CV Intra-individual variation (%) |
CV Inter-individual variation (%) |
ICC | iAUC | CV Intra-individual variation (%) |
CV Inter-individual variation (%) |
ICC | |
| C-peptide | 672 (276; 1269) | 18.2 (2.6; 40.3) | 74.2 | 0.69 | 759 (377; 1339) | 16.9 (0.6; 77.9) | 42.7 (41.6; 43.9) | 0.51 |
| Insulin | 5456† (2363; 9281) | 19.7† (2.2; 52.4) | 70.5† | 0.70 | 7082§ (2473; 17,080) | 20.5§ (5.2; 61.8) | 69.0§ (64.6; 73.4) | 0.59 |
| Glucose | 4435 (− 1706; 12,671) | 18.9 (− 80.7; 74.9) | 207.7 | 0.89 | 5276 (810; 15,270) | 45.9 (6.9; 97.2) | 69.1 (66.6; 71.6) | 0.53 |
Data are means, coefficient of variation (CV), minimum and maximum and intraclass correlation coefficient (ICC). Data are given in ng*ml−1 *3 h−1 for iAUC C-peptide, mU*l−1*3 h−1for iAUC insulin, mg*dl−1*3 h−1 for iAUC glucose
Data are available for §n = 17 out of 20 measurements or †n = 27 out of 30 measurements
iAUC, incremental area under the curve; CV, coefficient of variation; ICC, intraclass correlation coefficient; MMTT, mixed meal tolerance test