Table 3.
Odds ratios for patient characteristics associated with warfarin use after atrial fibrillation diagnosis
| Warfarin use | ||||||
|---|---|---|---|---|---|---|
| Within 30 days | Within 60 days | Within 90 days | ||||
| Characteristics | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p |
| Age, years | ||||||
| 0–49 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| 50–64 | 1.03 (0.85–1.25) | 0.7443 | 1.04 (0.86–1.25) | 0.6952 | 1.03 (0.86–1.23) | 0.7476 |
| 65–74 | 1.09 (0.89–1.33) | 0.4054 | 1.10 (0.91–1.33) | 0.3261 | 1.08 (0.90–1.30) | 0.4036 |
| 75–84 | 0.96 (0.77–1.20) | 0.7361 | 0.99 (0.81–1.22) | 0.9349 | 0.99 (0.81–1.20) | 0.8842 |
| ≥85 | 0.53 (0.38–0.75) | 0.0003 | 0.49 (0.35–0.68) | < 0.0001 | 0.52 (0.38–0.71) | <0.0001 |
| Sex | ||||||
| Male | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| Female | 1.01 (0.90–1.13) | 0.9122 | 0.96 (0.86–1.07) | 0.4764 | 0.99 (0.89–1.09) | 0.7790 |
| Race | ||||||
| White | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| Black | 0.80 (0.71–0.91) | 0.0006 | 0.80 (0.71–0.90) | 0.0002 | 0.79 (0.70–0.88) | <0.0001 |
| Asian | 0.57 (0.43–0.76) | 0.0002 | 0.61 (0.47–0.79) | 0.0003 | 0.63 (0.49–0.81) | 0.0003 |
| Other | 0.74 (0.49–1.12) | 0.1504 | 0.74 (0.50–1.10) | 0.1386 | 0.88 (0.61–1.26) | 0.4817 |
| Primary cause of end-stage renal disease | ||||||
| Diabetes mellitus | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| Hypertension | 1.02 (0.87–1.19) | 0.7982 | 0.98 (0.85–1.14) | 0.8222 | 0.97 (0.84–1.12) | 0.7037 |
| Glomerulonephritis | 1.03 (0.83–1.27) | 0.8110 | 0.99 (0.81–1.21) | 0.9299 | 1.04 (0.85–1.26) | 0.7191 |
| Other cause | 0.84 (0.69–1.02) | 0.0714 | 0.82 (0.68–0.98) | 0.0311 | 0.83 (0.70–0.99) | 0.0359 |
| Years on dialysis | ||||||
| 1–2 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| 3–4 | 1.02 (0.88–1.19) | 0.7747 | 1.02 (0.88–1.17) | 0.8138 | 0.99 (0.86–1.13) | 0.8776 |
| 5–9 | 1.07 (0.92–1.24) | 0.3919 | 1.07 (0.93–1.23) | 0.3502 | 1.06 (0.92–1.21) | 0.4272 |
| ≥10 | 1.15 (0.97–1.38) | 0.1166 | 1.15 (0.97–1.36) | 0.1088 | 1.10 (0.94–1.30) | 0.2410 |
| Atrial fibrillation diagnosis setting | ||||||
| Inpatient | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| Outpatient | 0.47 (0.40–0.54) | < 0.0001 | 0.52 (0.45–0.59) | < 0.0001 | 0.58 (0.50–0.66) | <0.0001 |
| Diabetes mellitus | 1.00 (0.86–1.16) | 0.9930 | 0.99 (0.86–1.14) | 0.8782 | 0.99 (0.87–1.14) | 0.9103 |
| Atherosclerotic heart disease | 0.93 (0.83–1.05) | 0.2533 | 0.88 (0.79–0.99) | 0.0281 | 0.88 (0.79–0.98) | 0.0200 |
| Congestive heart failure | 1.07 (0.95–1.20) | 0.2944 | 1.08 (0.97–1.22) | 0.1669 | 1.10 (0.98–1.23) | 0.0908 |
| Dysrhythmia | 0.91 (0.75–1.09) | 0.3025 | 0.86 (0.72–1.02) | 0.0768 | 0.91 (0.78–1.07) | 0.2609 |
| Other cardiac disease | 0.97 (0.86–1.09) | 0.6129 | 0.95 (0.85–1.06) | 0.3844 | 0.96 (0.86–1.07) | 0.4577 |
| Stroke/transient ischemic attack | 1.03 (0.88–1.20) | 0.7237 | 1.04 (0.90–1.20) | 0.5856 | 1.08 (0.94–1.25) | 0.2519 |
| Peripheral vascular disease | 0.94 (0.84–1.06) | 0.3531 | 1.00 (0.89–1.12) | 0.9598 | 1.03 (0.93–1.15) | 0.5665 |
| Chronic obstructive pulmonary disease | 1.12 (0.99–1.28) | 0.0814 | 1.10 (0.98–1.25) | 0.1195 | 1.10 (0.98–1.24) | 0.1110 |
| Gastrointestinal bleeding | 0.52 (0.42–0.65) | < 0.0001 | 0.58 (0.48–0.71) | < 0.0001 | 0.60 (0.50–0.73) | <0.0001 |
| Liver disease | 0.82 (0.67–1.01) | 0.0665 | 0.86 (0.71–1.04) | 0.1194 | 0.80 (0.66–0.97) | 0.0206 |
| Cancer | 0.81 (0.65–1.00) | 0.0553 | 0.91 (0.74–1.11) | 0.3303 | 0.87 (0.72–1.06) | 0.1720 |
| Drug or alcohol abuse | 0.43 (0.20–0.96) | 0.0397 | 0.36 (0.16–0.79) | 0.0111 | 0.32 (0.15–0.71) | 0.0049 |
| Disability proxy score | ||||||
| ≤0 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||
| 1–2 | 0.76 (0.66–0.87) | 0.0001 | 0.76 (0.67–0.87) | < 0.0001 | 0.75 (0.66–0.86) | <0.0001 |
| 3–4 | 0.57 (0.49–0.68) | < 0.0001 | 0.61 (0.53–0.72) | < 0.0001 | 0.62 (0.53–0.71) | <0.0001 |
| 5–6 | 0.42 (0.34–0.53) | < 0.0001 | 0.49 (0.40–0.60) | < 0.0001 | 0.51 (0.42–0.62) | <0.0001 |
| ≥7 | 0.44 (0.33–0.58) | < 0.0001 | 0.45 (0.35–0.59) | < 0.0001 | 0.46 (0.36–0.58) | <0.0001 |