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. 2021 May 5;19:130. doi: 10.1186/s12951-021-00869-6

Scheme 1.

Scheme 1

Schematic Illustration of preparation of the hybrid hydrogel dressing. The siMMP-9 is first complexed with GT, then GT/siMMP-9 is mixed completely with PF-127 and methylcellulose. This hybrid hydrogel undergoes a sol-gel transition in situ and then deliver sustained siMMP-9 to the diabetic wound area