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. Author manuscript; available in PMC: 2021 May 5.
Published in final edited form as: Nat Genet. 2020 Sep 28;52(10):1024–1035. doi: 10.1038/s41588-020-0696-0

Extended Data Fig. 2. Histone posttranslational modifications in Younger, Old and AD.

Extended Data Fig. 2

(a) Amino acid sequence of canonical histone H3 (H3.1 and H3.2) tail and globular domain, and its H3.3 variant. The residue that differs between canonical H3 and H3.3 is highlighted in red. (b) Amino acid sequence of histone H4 tail and globular domain. Bars below the amino acid sequence in panels a-b represent peptides generated in the trypsinization process that were identified on the mass spectrometer (LC-MS/MS). Grey bars represent peptides not reliably detected and therefore excluded from the analysis. (c-e) Stacked bar plots showing relative abundance of histone modifications (methylation and acetylation) on histones H3, H3.3 and H4 in (c) Younger, (d) Old and (e) AD. The lysine residues (K) analyzed are listed below the stacked bar plots.