Table 1.
Univariate and multivariable analysis of factors associated with SARS-CoV-2 seropositivity.
| Total | Seropositive (n = 253) |
Seronegative (n = 3002) |
Univariate analysis |
Multivariate analysis |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | % | No. | % | OR [95%CI] | P-value | OR [95%CI] | P-value | ||||
| Sex | 0.01 | 0.01 | |||||||||
| Female | 2513 | 77.9% | 211 | 8.4% | 2302 | 91.6% | 1.58 [1.11; 2.25] | 1.61 [1.11; 2.32] | |||
| Male | 712 | 22.1% | 39 | 5.5% | 673 | 94.5% | 1 | 1 | |||
| Missing | 30 | 3 | 10.0% | ||||||||
| Age (years) | 0.017 | 0.15 | |||||||||
| Mean ± SD | 41.9 ± 12.4 | 40.1 ± 10.6 | 42.0 ± 12.5 | ||||||||
| Median (min - max) | 41 (0 - 120) | 39 (22 - 64) | 41 (0 - 120) | ||||||||
| < 30 | 662 | 20.4% | 50 | 7.6% | 612 | 92.4% | 1.26 [0.86; 1.85] | 1.25 [0.92; 1.70] | |||
| 30 - 49 | 1539 | 47.4% | 139 | 9.0% | 1400 | 91.0% | 1.53 [1.12; 2.08] | ||||
| 50 - 65 | 1049 | 32.3% | 64 | 6.1% | 985 | 93.9% | 1 | 1 | |||
| Patient-facing occupational work | 0.08 | 0.40 | |||||||||
| No | 750 | 23.0% | 47 | 6.3% | 703 | 93.7% | 1 | 1 | |||
| Yes | 2495 | 76.7% | 205 | 8.2% | 2290 | 91.8% | 1.34 [0.96; 1.86] | 0.83 [0.55; 1.27] | |||
| Work in a COVID-19 unit | < 0.001 | < 0.001 | |||||||||
| No | 2125 | 65.3% | 126 | 5.9% | 1999 | 94.1% | 1 | 1.64 [1.21; 2.23] | |||
| Yes | 1130 | 34.7% | 127 | 11.2% | 1003 | 88.8% | 2.01 [1.55; 2.60] | 1 | |||
| Work department | 0.015 | 0.30 | |||||||||
| Nursing | 1490 | 45.8% | 145 | 9.7% | 1345 | 90.3% | 1.57 [1.09; 2.25] | 1.04 [0.66; 1.63] | |||
| Medical | 1067 | 32.8% | 60 | 5.6% | 1007 | 94.4% | 0.87 [0.57; 1.31] | 0.79 [0.51; 1.24] | |||
| Pharmacy | 77 | 2.4% | 8 | 10.4% | 69 | 89.6% | 1.68 [0.76; 3.74] | 1.49 [0.65; 3.40] | |||
| Administration and others | 621 | 19.1% | 40 | 6.4% | 581 | 1.00 | 1 | ||||
| Exposure to a COVID-19 patient | < 0.001 | 0.08 | |||||||||
| No | 2167 | 66.6% | 138 | 6.4% | 2029 | 93.6% | 1 | 1 | |||
| Yes | 1088 | 33.4% | 115 | 10.6% | 973 | 89.4% | 1.74 [1.34; 2.25] | 1.30 [0.97; 1.74] | |||
| Exposure to a COVID-19 colleague | < 0.001 | 0.016 | |||||||||
| No | 1964 | 60.3% | 118 | 6.0% | 1846 | 94.0% | 1 | 1 | |||
| Yes | 1291 | 39.7% | 135 | 10.5% | 1156 | 89.5% | 1.83 [1.41; 2.36] | 1.41 [1.06; 1.87] | |||
| Days of eWork | 0.014 | 0.28 | |||||||||
| 0 | 2729 | 83.8% | 226 | 8.3% | 2503 | 91.7% | 1.67 [1.11; 2.52] | 1.28 [0.81; 2.02] | |||
| ≥1 | 526 | 16.2% | 27 | 5.1% | 499 | 94.9% | 1 | 1 | |||
| Mean ± SD | 2.4 ± 1.3 | 2.3 ± 1.1 | 2.4 ± 1.3 | ||||||||
| Median (min - max) | 2 (1 - 15) | 2 (1 - 5) | 2 (1 - 15) | ||||||||
| Cohabitant working in health care | 0.013 | 0.002 | |||||||||
| No | 2529 | 81.1% | 197 | 7.8% | 2332 | 92.2% | 1 | 1 | |||
| Yes, in hospital | 561 | 18.0% | 37 | 6.6% | 524 | 93.4% | 0.84 [0.58; 1.20] | ||||
| Yes, in care and rest home | 30 | 1.0% | 8 | 26.7% | 22 | 73.3% | 4.30 [1.89; 9.79] | 3.71 [1.59; 8.65] | |||
| Cohabitant infected with SARS-CoV-2 | < 0.001 | < 0.001 | |||||||||
| No | 2727 | 83.8% | 130 | 4.8% | 2597 | 95.2% | 1 | 1 | |||
| Yes | 271 | 8.3% | 46 | 17.0% | 225 | 83.0% | 4.08 [2.84; 5.87] | 2.55 [1.78; 3.66] | |||
| Having chidren | 0.17 | ||||||||||
| No | 1274 | 39.1% | 109 | 8.6% | 1165 | 91.4% | 1 | ||||
| Yes | 1976 | 60.7% | 143 | 7.2% | 1833 | 92.8% | 0.83 [0.64; 1.08] | ||||
| >12 years | 0.07 | ||||||||||
| 0 | 960 | 48.6% | 59 | 6.1% | 901 | 93.9% | 1 | ||||
| ≥1 | 1016 | 51.4% | 84 | 8.3% | 932 | 91.7% | 1.38 [0.97; 1.94] | ||||
| Mean ± SD | 1.8 ± 0.9 | 1.9 ± 0.8 | 1.8 ± 0.9 | ||||||||
| Median (min - max) | 2 (1 - 6) | 2 (1 - 4) | 2 (1 - 6) | ||||||||
| < 6 years | 0.96 | ||||||||||
| 0 | 1372 | 69.4% | 99 | 7.2% | 1273 | 92.8% | 1 | ||||
| ≥1 | 604 | 30.6% | 44 | 7.3% | 560 | 92.7% | 1.01 [0.70; 1.46] | ||||
| Mean ± SD | 1.6 ± 0.7 | 1.7 ± 0.7 | 1.6 ± 0.7 | ||||||||
| Median (min - max) | 1 (1 - 4) | 2 (1 - 3) | 1 (1 - 4) | ||||||||
| Childcare facilities | 0.59 | ||||||||||
| Yes | 298 | 49.3% | 24 | 8.1% | 282 | 94.6% | 1.18 [0.64; 2.19] | ||||
| No | 306 | 50.7% | 20 | 6.5% | 278 | 90.8% | 1 | ||||
| Influenza vaccine | 0.70 | ||||||||||
| No | 2229 | 68.5% | 170 | 7.6% | 2059 | 92.4% | 1 | ||||
| Yes | 1023 | 31.4% | 82 | 8.0% | 941 | 92.0% | 1.06 [0.80; 1.39] | ||||
| COVID-19 symptoms | < 0.001 | ||||||||||
| No | 1801 | 55.3% | 37 | 2.1% | 1764 | 97.9% | 1 | ||||
| Yes | 1447 | 44.5% | 215 | 14.9% | 1232 | 85.1% | 8.32 [5.83; 11.88] | ||||
| SARS-CoV-2 molecular test | < 0.001 | ||||||||||
| No | 2613 | 80.3% | 108 | 4.1% | 2505 | 95.9% | 1 | ||||
| Yes | 642 | 19.7% | 145 | 22.6% | 497 | 77.4% | 6.77 [5.18; 8.83] | ||||
| Positive | 515 | 80.2% | 33 | 6.4% | 482 | 93.6% | |||||
| Negative | 127 | 19.8% | 112 | 88.2% | 15 | 11.8% | |||||