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. 2021 Apr 21;12:624582. doi: 10.3389/fphar.2021.624582

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Copyright © 2021 Molero-Chamizo, Salas Sánchez, Álvarez Batista, Cordero García, Andújar Barroso, Rivera-Urbina, Nitsche and Alameda Bailén.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pre- and post-anodal and sham tDCS values of pain intensity of the Adaptive Visual Analog Scales of pain intensity and improvement (AVAS) for each of the three patients (A–C) throughout the five intervention sessions (day 1–5). The dotted line indicates the data trend. Significant differences between pain intensity mean values of the anodal and sham tDCS conditions were found in each patient (p = 0.005, p = 0.007, p = 0.028, respectively), with reduced pain intensity values after anodal tDCS in patients 1 and 2.