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Potential mechanisms by which exercise, increases in core temperature and/or dehydration may increase the risk of acute kidney injury (AKI) while also promoting fluid conservation. Dashed lines indicate known beneficial physiological responses. Solid lines indicate potential pathogenic processes. Abbreviations – RAAS: renin-angiotensin-aldosterone system, RSNA: renal sympathetic nerve activity, PO2: partial pressure of oxygen, ATP: adenosine triphosphate
