Figure 3.

Haplotypes for associated HLA alleles. For a selection of associated HLA alleles, we show the most frequently observed risk (A) and protective (B) haplotypes in the respective populations. African American (AA), Puerto Rican (PRI), Caucasian (EUR), Maltese (MLT), Iranian (IRN), North Indian (IND), Chinese (CHN), Korean (KOR) and Japanese (JPN). Here we show only DRB1-DQA1-DQB1 haplotypes with a frequency > 1% in the case individuals in each respective population. The most frequently observed C-B alleles in each population were then added if the C-B-DRB1-DQA1-DQB1 haplotype occurred in more than or equal to five individuals. HLA-DRB3/4/5 alleles were taken from (15) and calculated on the basis of individuals hemizygous for HLA- DRB3/4/5 (i.e. carrying only one HLA-DRB1 observed with either HLA-DRB3, -DRB4 or -DRB5 and one DRB1^*01, DRB1^*08 or DRB1^*10, which are not observed with any of the HLA- DRB3/4/5.)