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. 2021 May 5;42(Suppl 1):89–97. doi: 10.1007/s00292-021-00945-6

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© The Author(s) 2021

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Fig. 2 — Histomorphological characteristics of regional lymph nodes of COVID-19 lungs. a Moderate to severe edema with capillary stasis (H&E; 50 ×). b Proliferation of extrafollicular plasmablasts (H&E; 200 ×). c, d IgG (c) and IgM (d) staining of plasmablasts (immunoperoxidase; 400 ×). e Hemophagocytosis in the sinus of a lymph node (H&E; 360 ×). Left inlet: positivity for CD11c in histiocytes undergoing hemophagocytosis (immunoperoxidase; 400 ×); right inlet: positivity for CD206, a specific marker of M2 polarization [48], in sinus histiocytes