Fig. 10. Helical wheel diagrams illustrating subtle staple placement; (a) at the boundary between hydrophobic and hydrophilic surfaces which is likely to result in improved uptake due to expansion of hydrophobic surface area; (b) to form a contiguous hydrophobic surface which is likely to confer superior uptake. Hydrophobic residues and staples are shown in orange, and hydrophilic and positively charged residues are shown in blue.