Fig. 5. Comparison of constrained p53/hDM2 structures; (a) the binding site formed in the crystallographically unique M06 complex is capped by the ‘hinge’ helix of the hDM2 lid (PDB: 4UMN); (b) the binding pockets that form when hDM2 interacts with SAH-8 (PDB: 3V3B);62 (c) The ‘hinge’ helix caps the bottom of the pocket; (d) Tyr100 (green) adopts the ‘closed’ conformation and forms a hydrogen bond interaction with Asn29.65.
