Fig. 2. Quantitative chemoproteomic profiling of itaconated proteins by C3A in S. enterica lysates. (A) Workflow for the triplex dimethylation-based quantitative chemoproteomic profiling of itaconated proteins in S. enterica by C3A. (B) Overlap of the itaconated proteins identified by C3A in four biological replicates. (C) Distribution of the averaged enrichment and competition ratios of the C3A-labeled proteins. (D) Bioinformatics analysis of the prominent 197 itaconated protein targets in terms of functional annotation and cellular location.
