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. 2021 Feb 15;32(4):331–347. doi: 10.1091/mbc.E20-07-0492

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FIGURE 5: — Epistatic and synthetic interaction between mec-7 neomorphs. (A) Short ALM-PNs in animals carrying T149I and A302V single mutations of mec-7 and the T149I C303Y and A302V C303Y double mutations. (B) Length of ALM-PNs in young adults of various mutants. Double asterisks indicate significant difference (p < 0.01). T149I and A302V single mutants were compared with WT. (C) Elongated PLM-PN in mec-7 weak neo alleles carrying G223E or R86C mutation. (D) Quantification of PLM-PN length in young adults of indicated mutants. Double asterisks indicate significant difference (p < 0.01) compared with WT. (E) Length of ALM-PNs in young adults of mec-17(-), mec-7(R86C), mec-7(G223E), and mec-12(P63S) single mutants and mec-17(-) double mutants with these mec-7 and mec-12 mutations. Double asterisks indicate significant difference (p < 0.01); mec-12(P63S) was compared with WT in B. (F) Anterior overextension of PLM-AN in mec-7(C303Y A302V) double mutants but not in mec-7(A302V) single mutants. (H) Distance from the PLM-AN terminals to the vulva in mec-7 neo single and double mutants. (G) Schematic diagram of ALM and PLM morphology in mec-7 neo single and double mutants. (I) The percentage of PLM-ANs that did not have synaptic branches in the indicated strains.