Table 3.
Regression coefficients derived from generalised Cox regression in OCTO (including the global composite score)
| Variable | Coefficient (SE) | P Value |
|---|---|---|
| Baseline Hazard 1 | −9.45 (4.04) | 0.02 |
| Baseline Hazard 2 | −6.09 (3.91) | 0.12 |
| Baseline Hazard 3 | −5.69 (3.93) | 0.15 |
| NPH (cogd, time):1 | −1.78 (1.96) | 0.36 |
| NPH (cogd, time):2 | 2.37 (0.72) | 0.001 |
| NPH (cogd, time):3 | −3.54 (1.05) | <0.001 |
| NPH (cogd, time):4 | 1.63 (0.98) | 0.096 |
| Cognitively inactive (yes vs. no) | 0.14 (0.24) | 0.56 |
| Physically inactive (yes vs. no) | −0.14 (0.24) | 0.57 |
| BMI | 0.01 (0.03) | 0.78 |
| SES (Low vs. High) | 0.07 (0.24) | 0.77 |
| Gender (Female vs. Male) | −0.30 (0.23) | 0.195 |
| Years of education | 0.03 (0.06) | 0.65 |
| Age at baseline | 0.04 (0.05) | 0.41 |
| Stroke ever (yes vs. no) | −0.02 (0.31) | 0.96 |
| High BP ever (yes vs. no) | −0.04 (0.23) | 0.87 |
| Diabetes ever (yes vs. no) | 0.36 (0.31) | 0.25 |
| Zygosity (yes vs. no) | −0.01 (0.23) | 0.97 |
| ApoEe4 (yes vs. no) | 0.47 (0.24) | 0.05 |
| Global Composite Score | −0.64 (0.197) | 0.001 |
Note: NPH- nonproportional hazards; cogd – cognitive dispersion; BMI – body mass index; SES – social economic status; cogd was modelled with a NPH spline with one knot positioned at 4 (study time). Statistically significant values are shown in bold.