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. Author manuscript; available in PMC: 2022 Feb 3.
Published in final edited form as: Neuroreport. 2021 Feb 3;32(3):238–243. doi: 10.1097/WNR.0000000000001575

Figure 2.

Figure 2.

The anti-nociceptive effect of 15d-PGJ2 in carrageenan-induced mechanical muscle hyperalgesia is PPARγ receptor-dependent. (A) PPARγ receptor antagonist, GW9662 was administered 15 minutes before 15d-PGJ2 and behavior was quantified 3h after carrageenan (B) Pre-treatment with GW9662 (3 and 9, but not 1 ng or vehicle) significantly prevented the anti-nociceptive effect of 15d-PGJ2, when tested 3h after carrageenan (Cg) injection (Tukey post-tests: * P < 0.05 n = 5). (C) Pre-treatment with GW9662 prevented the anti-hyperalgesic effect of 15d-PGJ2 in a dose-dependent manner (nonlinear regression analysis, p<0.05; ED50 = 4.1ng n = 4–5).