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. 2021 May 5;9(3):e00755. doi: 10.1002/prp2.755

FIGURE 2.

FIGURE 2

FRDA patient fibroblasts exhibit increased mitochondrial fragmentation and decreased ATP levels compared to healthy fibroblasts. FRDA patient cells have an increased number of mitochondrial fragments (A–C) and lower levels of FXN (D–E). They have an increased number of (Ser616) phospho‐Drp1 clusters (F–H) but no significant change to (Ser616) phospho‐Drp1 or Drp1 levels (I–J). 0 ATP levels are decreased (K). *p < .05, n.s. not significant