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. 2021 Apr 21;12:649440. doi: 10.3389/fgene.2021.649440

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Copyright © 2021 Calderer and Kuijjer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic visualization of bipartite community detection and its applications to large-scale biological networks. (A) An example of two communities (C1 and C2) detected in a bipartite network. (B) Possible applications of bipartite community detection in the analysis of large-scale biological networks. This includes pathway enrichment in communities, enrichment analysis of other biological properties by testing against external data, identification of “local hub” genes that are central to their community, node similarity detection, and community structure comparison between, for example,networks modeled on disease and control samples.