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. 2021 Apr 15;12:651976. doi: 10.3389/fphar.2021.651976

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Copyright © 2021 Fan, Wang, Huang, Li, Ma, Yao, Tang, Xue, Ha, Ren, Zhang, Wang, Xie, Luo, Tan and Gu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The chemical structure involved in this study. (A) Three common fragments of TMP derivatives. (B) Some current reported Stat3 inhibitors. (C) From E28 to Statmp series which was via rational drug design and virtual screening.