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. 2021 May 5;2021(5):CD007899. doi: 10.1002/14651858.CD007899.pub3
Country Study ID Study design Random sequence generation (low = random, high = not random, unclear if not specified) Allocation concealment Baseline outcome measurement similar Baseline characteristics similar Incomplete outcome data
Argentina Gertler 2014 CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences Low except high for neonatal mortality (noted imbalance only for this outcome). Low: paper mentioned missingness of 3%, similar across groups. Complete‐case analyses were conducted, which may compromise results but no reporting of missingness by outcome.
Burkina Faso Steenland 2017 CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. High – Table 1 suggested differences between comparison and intervention existed, e.g. number of health facilities/100,000 people consistently higher in intervention than in comparator group. Low – see Appendix Table 4 of Steenland 2017.
Burundi Bonfrer 2014a CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. High – appendix Table 6 of Bonfrer 2014a suggests differences existed between the different districts, e.g. population characteristics (poverty) varied between 28.7% and 82.3%. Unclear: not specified.
Bonfrer 2014b CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. Low – comparable. Unclear: not specified.
Falisse 2015 CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. High – data not presented. Low – authors noted outcomes to focus on chosen based on completeness and sensitivity analyses conducted.
Rudasingwa 2014 CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. High – data not presented. Low – authors noted outcomes to focus on chosen based on completeness.
Cambodia Van de Poel 2016 CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. Low – comparable. Unclear: not specified.
Cameroon Zang 2015 CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. Low – comparable. Unclear: not specified.
China Yao 2008 CBA High – as per guidance. High – as per guidance. Paper reanalyzed; reanalyzed results noted as low (analysis methods adjusted for differences). High – Table 1 of Yao 2008 suggests the intervention was performed in areas that were more populated and poorer compared to control. Unclear: not specified.
Democratic Republic of the Congo Zeng 2018 CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. High – Table 3 of Zeng 2018 suggests significant differences, e.g. in household size, daily spending and age of mother. Unclear: not specified.
Soeters 2011 CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. High – not specified. Unclear: not specified.
El Salvador Bernal 2018 CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. High – Table 2 and page 9 of Bernal 2018 highlight the differences between results‐based aid provinces and those with national funding. Unclear: not specified.
Haiti Zeng 2013 CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. High – data not presented. Unclear: not specified.
Multiple – Burkina Faso, Ghana and Tanzania Duysburgh 2016 CBA High – as per guidance. High – as per guidance. Paper reanalyzed; reanalyzed results noted as low (analysis methods adjusted for differences). High – appendix Table S1 of Duysburgh 2016 suggested differences between intervention and control sites but unclear what effect this would have on outcomes. Unclear: not specified.
Tanzania Binyaruka 2015 CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. Low except for: ANC visits and IPT during ANC, outpatient visits per month < or > 5, patient assessments of staff kindness, probability of payment for delivery care, satisfaction with interpersonal care. High: authors noted this may have biased results.
Binyaruka 2017 CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. Low except for: availability and stockouts of medicines and medical supplies Unclear: not specified.
Binyaruka 2018b CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. Low except for: ANC visits and IPT during ANC, outpatient visits per month < or > 5, patient assessments of staff kindness, probability of payment for delivery care, satisfaction with interpersonal care. High: authors noted that this may have biased results.
Mayumana 2017 CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. Low except for: medical supply stockouts, disruptions due to broken equipment, governance outcomes (committee meetings, content of supervision, existence of community health fund). High: authors noted that this may have biased results.
Zimbabwe Das 2017 CBA High – as per guidance. High – as per guidance. Low – analysis methods adjusted for differences. Low – comparable. High: subset analyses with particularly small samples.
Benin Lagarde 2015 Quasi/non‐randomized trial Unclear: not specified. Unclear: not specified. High – analyses methods did not adjust for baseline differences in outcomes, but do adjusted for facility and health worker differences. High – appendix Table 6 of Lagarde 2015 suggested differences exist between the different districts, e.g. population characteristics (poverty) varied between 28.7% and 82.3%. Unclear: not specified.
Cameroon de Walque 2017 Quasi/non‐randomized trial Low – sequence described in sufficient detail. Low – assignment by province/district/cluster. Low – analysis methods adjusted for differences. Low – comparable. Unclear: not specified.
China Powell‐Jackson 2014 Quasi/non‐randomized trial High – no randomization, though matching occurred. Low – assignment by province/district/cluster. Low – analysis methods adjusted for differences. Low – comparable. Unclear: not specified.
Sun 2016 Quasi/non‐randomized trial High – randomization compromised. Low – assignment by province/district/cluster. Low – analysis methods adjusted for differences. Low – comparable. Unclear: not specified.
Peru Cruzado de la Vega 2017 Quasi/non‐randomized trial High – no randomization. Low – assignment by province/district/cluster. Low – analysis methods adjusted for differences. Low – comparable. Unclear: not specified.
Rwanda Basinga 2011 Quasi/non‐randomized trial High – randomization compromised. Low – assignment by province/district/cluster. Low – analysis methods adjusted for differences. Low – comparable. Unclear: not specified.
Lannes 2016 Quasi/non‐randomized trial High – randomization compromised. Low – assignment by province/district/cluster. Low – analysis methods adjusted for differences. Low – comparable. Unclear: not specified.
Priedeman Skiles 2013 Quasi/non‐randomized trial High – randomization compromised. Low – assignment by province/district/cluster. Low – analysis methods adjusted for differences. Low – comparable. Unclear: not specified.
Priedeman Skiles 2015 Quasi/non‐randomized trial High – randomization compromised. Low – assignment by province/district/cluster. Low – analysis methods adjusted for differences. Low – comparable. Unclear: not specified.
Sherry 2017 Quasi/non‐randomized trial High – randomization compromised. Low – assignment by province/district/cluster. Low – analysis methods adjusted for differences. Low – comparable. Unclear: not specified.
Lannes 2015 Quasi/non‐randomized trial High – randomization compromised. Low – assignment by province/district/cluster. Unclear: not specified. High – not specified. Unclear: not specified, using data from Basinga 2011.
Gertler 2013 Quasi/non‐randomized trial High – randomization compromised. Low – assignment by province/district/cluster. Low – analysis methods adjusted for differences. Low – comparable. Low – authors noted similar levels of attrition.
de Walque 2015 Quasi/non‐randomized trial High – randomization compromised. Low – assignment by province/district/cluster. Low – analysis methods adjusted for differences. Low – comparable. Unclear: not specified.
Swaziland Kliner 2015 Quasi/non‐randomized trial High – no randomization. High – allocation was pragmatic. Low – analysis methods adjusted for differences. High – Table 2 of Kliner 2015 suggested differences in populations and outcomes exist. Unclear: not specified.
Tanzania Brock 2018 Quasi/non‐randomized trial Low – sequence described in sufficient detail. Low – assignment by healthcare professional, done after baseline assessment. Low – comparable. High – Tables 2 and 3 of Brock 2018 suggested some differences between providers and patients. Low – dropout before assignment 12%, but after only 3%.
Zimbabwe Friedman 2016b Quasi/Non‐randomized trial High – no randomization, though stratification and matching. High – allocation was done by Ministry if Health via matching. Low – analysis methods adjusted for differences. Low – comparable. (Appendix 3 of Friedman 2016b tested parallel trends, though baseline characteristics were dissimilar at times). Unclear: not specified (authors noted that for household expenditure data there was high missingness).
ANC: antenatal care; CBA: controlled before‐after; IPT: intermittent preventive treatment.