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. 2021 May 5;7(19):eabf1244. doi: 10.1126/sciadv.abf1244

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Fig. 2 — (A) The approach for the screening of LNP library by prime-boost route. (B to D) The OVA-specific immunoglobulin G (IgG) (B), IgG1 (C), and IgG2c (D) antibody titers after immunization with OVA-loaded LNPs. n = 3. ^#The titer was lower than the minimal dilution. (E) The enhanced cytoplasmic delivery of antigens by LNPs up-regulated the cross-presentation. (F) Typical flow cytometry data of the expression of SIINFEKL–MHC I complex on DC2.4 cells after incubation of different formulation of OVA. (G) The MFI of labeled SIINFEKL–MHC I complex calculated by flow cytometry. n = 4.