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. 2021 May 5;7(19):eabf1244. doi: 10.1126/sciadv.abf1244

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Fig. 3 — (A) The activation of STING pathway by cytoplasmic delivery of cGAMP using 93-O17S-F. (B) Subcellular distribution of cGAMP^Fluo and lysosome in RAW264.7 and DC2.4 cells after incubation of free cGAMP^Fluo or 93-O17S-F/cGAMP^Fluo for 4 hours. (C and D) Relative expressions of ifnb1 (C) and cxcl10 (D) genes in RAW264.7 and DC2.4 cells after incubation of 93-O17S-F/cGAMP for 4 hours. n = 6, *P ≤ 0.05, **P ≤ 0.01, and ***P ≤ 0.001. (E) The concentration of IFN-β in the medium of DC2.4 cells after incubation of 93-O17S/cGAMP for 4 and 24 hours. n = 4.