Table.

Characteristics of Autonomic Failure Syndromes

	PAF	Park+	MSA
Level of the lesion	Peripheral	Peripheral	Central
Histopathology	Lewy bodies	Lewy bodies	Alpha‐synculein inclusions
CNS symptoms*	No	Yes	Yes
Response to L‐dopa	N/A	Good	Poor or none
Progression	Relatively good	Relatively good	Poor
PAF=pure autonomic failure; Park+=Parkinson's disease with autonomic failure; MSA= multiple system atrophy; CNS=central nervous system; *may include movement disorders or cerebral ataxia