FIGURE 1.

Treatment schedule/study conduct. The study comprised two screening visits (one medical and one environmental exposure chamber screening, EEC). Treatment was started at Visit 2. The patients continued the treatment for 13 days at home with two reminder phone calls in between (Visit 2a, 2b), before returning for a posttreatment EEC visit (Visit 3). Then, patients had a 7 days washout period and were crossed over to the alternate treatment at Visit 4. Similar to Period 1, treatment was continued for another 13 days. Then, a final EEC visit was performed (Visit 5, study end after 34 days). EEC, environmental exposure chamber