FIGURE 4.

Total ocular symptom score (TOSS). Data are expressed as mean + SEM. (A) TOSS change from baseline exhibited larger decreases for patients receiving ectoine at every time point in the EEC. Baseline is defined as the symptom scores at V2. (B) Mean TOSS area under the curve (AUC ) scores showed a significant reduction with ectoine and placebo treatment (***p = 0.0001, **p = 0.0059) comparing baseline values at V2 and posttreatment values (V3 and V5). (C) Patients receiving ectoine experienced larger reductions in TOSS than placebo‐treated patients as shown by AUC change from baseline. This reduction was statistically significant compared to placebo treatment (*p = 0.0227). EEC, environmental exposure chamber; SEM, standard error of the mean