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. 2021 Apr 27;10:e65108. doi: 10.7554/eLife.65108

Figure 1. Lack of adiponectin (APN) in aging mice shortens lifespan.

(A) Kaplan–Meier survival curves for wild-type (WT) and adiponectin null (APN-KO) mice on chow diet. (B) Kaplan–Meier survival curves for WT and APN-KO mice on high-fat diet (HFD). (C) Median survival time and maximum lifespan for each cohort. n denotes the number of mice per group.p-Values were determined by log-rank (Mantel–Cox) test.

Figure 1.

Figure 1—figure supplement 1. Mouse models used for longevity studies: adiponectin null (APN-KO) mice and adiponectin transgenic (ΔGly) mice.

Figure 1—figure supplement 1.

(A) Experimental strategy for longevity experiments. (B) Diagram of the aging process. Lifespan and healthspan are always strongly coupled. (C) Circulating adiponectin levels measured in 50-week-old APN-KO and ΔGly mice with their controls fed on chow diet, respectively (n = 4 per group).