(A) Expression of inflammatory and fibrosis markers in liver of 140-week-old wild-type (WT) and adiponectin null (APN-KO) mice fed on chow diet (n = 7 for WT, n = 7 for APN-KO mice). (B) Serum corticosterone level in 100-week-old WT and APN-KO mice fed on HFD or 140-week-old WT and APN-KO mice fed on chow diet (n = 5 per group). (C) IL1β, TNFα, CD11b, F4/80, CD206, Chil3 mRNA expression were measured from FACS-sorted hepatocytes and macrophages isolated from 100-week-old WT and APN-KO mice fed on HFD (n = 6 per group). Bar, 100 μm. Data are mean ± SEM. Student’s t test: *p<0.05, **p<0.01, ***p<0.001 for WT vs. APN-KO.