. 2021 Apr 19;10:e66014. doi: 10.7554/eLife.66014

Table 3. Prior distribution assigned to each parameter and initial molecular concentration.

*These distributions are centered around measurements obtained from cell surface receptor quantification experiments. **These distributions were derived based on $K_{d}$ values obtained from the literature (Wiederkehr-Adam et al., 2003). ***These distributions are based on values derived from experimental data in which the cells were treated with Tofacitinib. † These distributions were based on values derived from experimental data in which the cells were treated with cycloheximide. ‡These distributions were based on computations involving approximate cell sizes and average numbers of molecules per cell.

Parameter	Prior distribution	Reference
$r_{1,6}^{+}$	$10^{r} for r \sim N (- 3, 1.5)$	*
$r_{1,6}^{-}$	$10^{r} for r \sim N (- 3.9, 1.96)$	*
$r_{1,27}^{+}$	$10^{r} for r \sim N (- 2.34, 1.17)$	*
$r_{1,27}^{-}$	$10^{r} for r \sim N (- 2.82, 1.41)$	*
$r_{2, j}^{+}$ for j∈{6,27}	$10^{r} for r \sim U n i f (- 2, 3)$	Kozer et al., 2013
$r_{2, j}^{-}$ for j∈{6,27}	$10^{r} for r \sim U n i f (- 3, 1)$	Kozer et al., 2013
$k_{i a}^{+}$ , $k_{i b}^{+}$ for i∈{1,3}	$10^{r} for r \sim U n i f (- 7, 1)$	**
$k_{i a}^{-}$ , $k_{i b}^{-}$ for i∈{1,3}	$10^{r} for r \sim U n i f (- 2, 1)$	**
$q$	$10^{r} for r \sim U n i f (- 3, 2)$	Assumed
$d_{i}$ for i∈{1,3}	$10^{r} for r \sim U n i f (- 5, - 2)$	***
$β_{j}$ for j∈{6,27}	$10^{r} for r \sim U n i f (- 5, - 1)$	†
$γ_{j}$ for j∈{6,27}	$10^{r} for r \sim U n i f (- 5, - 1)$	†
$[R_{1} (0)]$	$N (12.7, 6.35)$	‡
$[R_{2} (0)]$	$N (33.8,16.9)$	‡
$[S_{1} (0)]$	$N (300,100)$	Itzhak et al., 2016
$[S_{3} (0)]$	$N (400,100)$	Itzhak et al., 2016