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Overview of in silico drug testing method. (a) Schematic of drug testing pipeline showing the use of both the fibroblast signaling network model and DrugBank repository to systematically test drug effects on cardiac fibroblasts. (b) A range of drug doses was simulated with 85% activity highlighted as having a strong effect on the target for nearly all drugs. Note that the heatmap rows have been expanded to only include one target on each row
