Fig. 1.

Contrast-enhanced MRI phenotype in tumors derived from murine, PDOX, and allograft models of MB. Representative T₂ weighted and T₁ weighted contrast-enhanced MR images and coregistered fusion images in MCre:Ptch1 (A, E, I), SHH PDOX (B, F, J), Gp3 PDOX (C, G, K), and ortho-MCre:Ptch1 (D, H, L). Tumor volumes are outlined in red dashed lines (A–H) and white dashed lines (I–L). A region of noncontrast enhancing tumor in SHH PDOX mice is highlighted by the yellow arrows (F and J). MB, medulloblastoma; MRI, magnetic resonance imaging; PDOX, patient-derived orthotopic xenograft; SHH, Sonic Hedgehog.