Fig. 3.

Vessel phenotype in tumors derived from murine, orthotopic PDOX, and allograft models of MB. Representative H&E and co-immunofluorescence microscopy of CD31 (red), Plvap (green), and Glut1 (red) costained with DAPI (blue) in MCre:Ptch1 (A, E, I), SHH PDOX (B, F, J), Gp3 PDOX (C, G, K), and ortho-MCre:Ptch1 (D, H, L). All images were acquired at ×80 total magnification. Scale bars: 50 μm. Blood vessels are outlined with a blue dashed line. MB, medulloblastoma; PDOX, patient-derived orthotopic xenograft; SHH, Sonic Hedgehog.