Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 1;23(5):732–742. doi: 10.1093/neuonc/noaa266

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

PMC Copyright notice

Fig. 4 — Markers of hypoxia are associated with all orthotopically transplanted models of MB. Representative IHC microscopy of HIF1α and CAIX in MCre:Ptch1 (A, E), SHH PDOX (B, F), Gp3 PDOX (C, G), and ortho-MCre:Ptch1 (D, H). All images were acquired at ×20 total magnification. Scale bars: 200 μm. Hypoxia-inducible factor 1 α binding sites within the promoter sequence of PLVAP (I). CAIX, carbonic anhydrase IX; HIF1α, hypoxia-inducible factor 1 subunit α; IHC, immunohistochemistry; MB, medulloblastoma; PDOX, patient-derived orthotopic xenograft; SHH, Sonic Hedgehog.