Table 1A.
Clinical, imaging, and histomolecular features of the 319 lower grade gliomas (IDH-mutated grades II and III) patients included in the study
| Clinical Features | |||
|---|---|---|---|
| Sex | Seizures | ||
| Male | 195 (61.1%) | Focal | 72/306 (23.5%) |
| Female | 124 (38.9%) | Generalized | 234/306 (76.4%) |
| Age | Handedness | ||
| Mean (SD) | 38.9(11.8) | Left | 316 (99.1%) |
| Median [Min Max] | 38 [18–75] | Right | 3 (0.9%) |
| Duration of Clinical History | Previous Treatments* | ||
| <6 months | 90 (28.2%) | No | 263 (82.4%) |
| >6 months | 229 (71.8%) | Yes | 56 (17.6%) |
| Reason For diagnosis | Dominance | ||
| Incidental | 13 (4.1%) | Left | 185 (58.0%) |
| Symptoms | 306 (95.9%) | Right | 134 (42.0%) |
| Preoperative imaging Features | |||
| Location | Side | ||
| Frontal | 140 (43.9%) | Left | 195 (61.1%) |
| Temporal | 56 (17.6%) | Right | 124 (38.9%) |
| Parietal | 45 (14.1%) | ||
| Insular | 78 (24.5%) | ||
| Involvement of eloquent sites | Involvement of CC | ||
| Close | 299 (93.7%) | Yes | 84 (26.3%) |
| Distant | 20 (6.3%) | No | 235 (73.7%) |
| Volume (cm3) | |||
| Mean (SD) | 65.2 (61) | ||
| Median [Min Max] | 46 [0.39–386] | ||
| Histomolecular and Tumor Grade Features | |||
| Integrated Diagnosis | Tumor Grade | ||
| Astrocytoma | 130 (40.8%) | II | 248 (77.7%) |
| Oligodendroglioma | 189 (59.2%) | III | 71 (22.3%) |
| Post operative Neurological Conditions | |||
| Immediate Deficits | Permanent Deficits | ||
| No | 26 (8.2%) | No | 313 (98.1%) |
| Yes | 293 (91.8%) | Yes | 6 (1.9%) |
Dominance: indicates if the tumor was located in the dominant hemisphere for language; involvement of eloquent sites considers the distance between the tumor margins and the location of cortical or subcortical sites anatomically related to main neurological functions (motor, language, visual, visuospatial) as visible in preoperative volumetric FLAIR; involvement of CC = involvement of corpus callosum as detectable in preoperative volumetric FLAIR; previous treatments includes partial resection followed by observation (31 cases) or chemotherapy (10), stereotactic biopsy followed by observation (9) or chemotherapy (6). Immediate deficits (at 5 days postsurgery); permanent deficits (at 1 month). For details see suppl.Methods.1.