Table 1B.
Clinical and imaging features of progression in the 319 IDH-mutant LGGs
| Total Population N = 319 | Progression N = 190 | |
|---|---|---|
| Gender | ||
| Male | 195 | 119 (61.0%) |
| Female | 124 | 71 (57.0%) |
| Age (mean; median) | ||
| Previous Treatment | 39; 38 | 40.2; 39 |
| Yes | 56 | 53 (94.7%) |
| No | 263 | 137 (53.6%) |
| Location | ||
| Frontal | 140 | 70 (50.0%) |
| Temporal | 56 | 29 (51.7%) |
| Parietal | 45 | 34 (75.6%) |
| Insular | 78 | 57 (73.1%) |
| Side | ||
| Left | 195 | 127 (65.1%)6 |
| Right | 124 | 63 (50.8%) |
| Involvement of eloquent sites | ||
| Close | 299 | 184 (61.5%) |
| Distant | 20 | 6 (30.0%) |
| Astro II | 89 | 61 (68.5%) |
| Oligo II | 159 | 77 (48.4%) |
| Astro III | 41 | 28 (68.3%) |
| Oligo III | 30 | 24 (80.0%) |
| Histolog. Confirmation | 74 (38.9%) | |
| Site of Progression | ||
| Cavity | 182 (95.8%) | |
| Distant | 8 (4.2%) |
Involvement of CC = involvement of corpus callosum.. Astro = astrocytoma; Oligo = oligodendroglioma; Histolog. Confirmation = indicates the cases in which transformation was confirmed by histological analysis subsequent to second surgery. Site of progression indicates the location of the progression in respect to the preexisting surgical cavity; Cavity = when the progression is within or at the border of the cavity; Distant = when the progression is far away from the preexisting resection cavity. We did not observe any leptomeningeal spread.