Table 1C.
Adjusted Cox regression analysis for PFS in Total and Supratotal groups. The adjusted analysis considered Extent of Resection (Supratotal ST vs Total T), integrated diagnosis (astrocytoma Astro vs oligodendroglioma Oligo) and grade at first diagnosis (III vs II). The model was adjusted for the factors that resulted significant in the univariate analysis, namely duration of clinical history, previous treatments, location, side,volume, Dominance, corpus callosum. Other variables were not considered as they involved a too restricted number of patients, namely reason for diagnosis, eloquent and permanent deficits. EOR and grade III at first diagnosis resulted significantly associated with PFS also after adjusting for the other variables.
| HR | 95% CI | P value | |
|---|---|---|---|
| ST vs T | 0.04 | 0.02–0.09 | <0.01 |
| Grade III vs Grade II | 1.94 | 1.19–3.14 | 0.01 |
| Integr.diagn. oligo vs astro | 0.74 | 0.48–1.14 | 0.18 |
| Duration clinical history >6 vs < 6 months | 0.66 | 0.42–1.03 | 0.07 |
| Previous Treats. | 1.93 | 1.19–3.13 | 0.01 |
| Location T. vs F. | 0.74 | 0.40–1.38 | 0.34 |
| Location P. vs F. | 1.07 | 0.61–1.86 | 0.82 |
| Location Ins. vs F | 1.05 | 0.62–1.79 | 0.84 |
| Righ vs Left | 0.70 | 0.38–1.31 | 0.27 |
| Volume mL | 1.00 | 0.99–1.00 | 0.30 |
| Dominant no vs yes | 0.73 | 0.38–1.38 | 0.33 |
| CC no vs yes | 0.77 | 0.49–1.22 | 0.27 |
ST, supratotal; T, Total; Integr.Diagn., integrated diagnosis; Oligo, oligodendroglioma; Astro, astrocytoma; Previous Treats., previous treatments; Location: T, temporal, F, frontal, P, parietal, Ins., insular. Dominant, dominance; CC, corpus callosum involvement.