Figure 3.

miR-499-enhanced IR-induced apoptosis of lung cancer A549 cells in vitro

(A) The effect of overexpression or silencing of miR-499 on IR-induced apoptosis detected by flow cytometry assay. (B) The effect of overexpression or silencing of miR-499 on IR-induced caspase-3, cleaved PARP, and cleaved caspase-3 protein expression determined by western blot analysis. ∗p < 0.05 versus cells treated with mimic NC; ^#p < 0.05 versus cells treated with inhibitor NC. The measurement data were expressed as mean ± standard deviation. Data between the two groups were compared using independent sample t test. The experiments were repeated for three times, with the representative result presented.