. 2021 Apr 2;10(3):100726. doi: 10.1016/j.imr.2021.100726

Table 1.

Characteristics of included randomized trials on SFJD capsules for AURTIs.

Study ID	Population	Sample size	Average age (year)	Male (%)	Time from symptom onset when included (Hours)	TCM syndrome differentiation	Baseline major symptoms	Intervention	Comparison	Treatment duration (days)	Measurement time of outcomes (days)	Outcomes reported^a
Common cold							Fever, cough
Chen H 2016 [22]	Children	78/78	6.3/6.5	44.9/52.6	NR	NR	>37.3℃	SFJD+ST +ribavirin	ST +ribavirin	7d	5d	2,3,6
Zhou XF 2016[23]	Children	70/70	5.1/4.8	48.6/44.348	48hr	Wind-heat syndrome	37.3–41.6℃	SFJD +ST+ ribavirin	ST+ ribavirin	5d	5d	2,3,6
Wang Q 2018[24]	Children	45/44	7.15/7.2	53.3/52.27	NR	NR	>37.3℃	SFJD +ST+ antivirals	ST+ antivirals	5d	5d	2,3,6
Zhang YP 2014[25]	Adults	110/110	40.2/39.81	54.5/59.0	NR	NR	>37.3℃	SFJD+ST	ST	7d	1d	1
Ye XQ 2013[26]	Adults	100/100	38.55/37.85	52/49	48hr	Wind-heat syndrome	37.3–39.0℃	SFJD+ST	ST	3d	3d	1,2,6
Zhao JL 2018[27]	Adults	61/62	45.69/45.21	49.1/53.2	NR	NR	>37.3℃	SFJD+ST	ST	3d	3d	1,6
Zhang B 2020[28]	Adults	119/118	31.94/35.94	56.8/54.6	NR	NR	37.3–39.0℃	SFJD+ST	ST	3d	3d	1,6
Xu YL 2015[29]	Adults	120/120	49.24/47.77	60/57.9	36hr	Wind-heat syndrome	37.3–39.0℃	SFJD	placebo	7d	3d	1,2,6
Wu XJ 2015[30]	Adults	112/119	70.9/70.8	59.8/59.8	NR	NR	>37.3℃	SFJD+ST+ antibiotics	ST+ antibiotics	7d	3d	1
Zhao LB 2020 [31]	Adults	78/78	37.3/36.8	52.3/51.3	36h	Wind-heat syndrome	37.1–39.1℃	SFJD +ST+ antivirals	ST+ antivirals	5d	5d	6
Acute rhinitis							Fever, stuffy nose
Li Y 2015[32]	Adults	30/30	49.2/50.3	43.3/46.7	72hr	Wind-heat syndrome	>37.3℃	SFJD+ST	ST	7d	5d	6
Herpangina							Fever, blisters
Yang Y 2019[33]	Children	35/35	4.55/4.2	51.4/42.9	48hr	NR	>37.3℃	SFJD +ST+ interferon	ST+ interferon	5d	5d	2,5,6
Yang ML 2016[34]	Children	123/123	4.2/4.1	49.6/47.9	48hr	NR	>37.3℃	SFJD+ST+ ribavirin	ST+ ribavirin	5d	5d	2,5,6
Liu CX 2015[35]	Children	37/33	2.4/2.5	NR	48hr	NR	37.3–41.0℃	SFJD +ST+ ribavirin	ST+ ribavirin	5d	5d	2,5,6
Acute pharyngitis							Fever, sore throat
Zhu SM 2019[36]	Adults	38/38	41.34/41.25	57.9/52.6	48hr	Wind-heat syndrome	37.3–38.5℃	SFJD+ ST	ST	5d	5d	4,6
Jiang JQ 2018[37]	Adults	48/48	37/39.81	47.9/43.8	48hr	NR	>37.3℃	SFJD+ST	ST	7d	5d	4,6
Dong W 2020[38]	Adults	45/45	30.1/32.1	48.89/53.33	36h	NR	>37.3℃	SFJD+ST	ST	6s	5d	2,4
Zhou QQ 2020[39]	Adults	106/106	32.75/30.63	69.8/74.53	48h	NR	NR	SFJD+ST	ST	7d	5d	4
Acute tonsillitis							Fever, sore throat
Zhang JY 2015[40]	Adults	45/45	22.94/24.17	68.9/60	48hr	NR	37.3–39.1℃	SFJD +ST+ cefaclor	ST+ cefaclor	7d	5d	2,4,6
Wang ZB 2018[41]	Adults	55/55	16.39/20.73	56.4/49.1	72hr	NR	>37.3℃	SFJD +ST+ amoxicillin	ST+ amoxicillin	7d	5d	2,4,6
Li G 2017[42]	Adults	50/50	27.1/27.3	56/52	NR	NR	≥38.0 ℃	SFJD +ST+ cefuroxime	ST+ cefuroxime	5d	5d	2,4,6
Li BR 2020[43]	Adults	50/50	22/21	52/42	NR	NR	>37.3℃	SFJD+ST+ penicillin	ST+ penicillin	7d	5d	2,4,6
Zhao ZY 2015[44]	Children	58/50	5.9/6.1	53.4/54	72hr	NR	≥38.0 ℃	SFJD +ST+ cefuroxime	ST+ cefuroxime	5d	5d	2,4,6
Yang X2017 [45]	Children	35/35	3.52/3.53	48.6/51.4	48hr	NR	38.4–39.8 ℃	SFJD +ST+ amoxicillin	ST+ amoxicillin	5d	5d	2,4,6
Huang PL 2016[46]	Children	60/60	7.12/6.74	51.7/53.3	72h	Wind-heat syndrome	>37.3℃	SFJD +ST+ cefaclor	ST+ cefaclor	6d	5d	2,4,6

Notes: AURTIs, acute upper respiratory tract infections; d, days; hr, hours; NR, not reported; SFJD, Shufeng Jiedu; ST, symptomatic treatment.

Outcomes: 1, Resolution rate of fever at day 3 of treatment; 2, Time to fever resolution; 3, Time to cough resolution; 4, Time to sore throat resolution; 5, Time to blister resolution; 6, Cure rate.

1–5 were primary outcomes, 6 was secondary outcome.