Table 15.
Individual animal body weights (g) data at Phase I.
|
Day 1 (Male) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| A # | G1 | A# | G2 | A# | G3 | A# | G4 | A# | G5 |
| 1 | 196.78 | 4 | 197.71 | 7 | 198.67 | 10 | 200.60 | 13 | 206.79 |
| 2 | 209.21 | 5 | 205.40 | 8 | 208.41 | 11 | 206.41 | 14 | 201.91 |
| 3 | 215.03 | 6 | 222.38 | 9 | 220.21 | 12 | 222.48 | 15 | 230.61 |
| Mean | 207.01 | 208.50 | 209.10 | 209.83 | 213.10 | ||||
| SD | 9.322 | 12.623 | 10.786 | 11.334 | 15.356 | ||||
| Day 3 (Male) | |||||||||
| A # | G1 | A# | G2 | A# | G3 | A# | G4 | A# | G5 |
| 1 | 209.30 | 4 | 215.25 | 7 | 218.66 | 10 | 214.44 | 13 | 217.70 |
| 2 | 229.37 | 5 | 220.32 | 8 | 222.31 | 11 | 226.42 | 14 | 212.60 |
| 3 | 228.39 | 6 | 240.40 | 9 | 242.49 | 12 | 238.60 | 15 | 250.80 |
| Mean | 222.35 | 225.32 | 227.82 | 226.49 | 227.03 | ||||
| SD | 11.315 | 13.301 | 12.835 | 12.080 | 20.740 | ||||
| Day 1 (Female) | |||||||||
| A # | G1 | A# | G2 | A# | G3 | A# | G4 | A# | G5 |
| 16 | 162.21 | 19 | 152.22 | 22 | 157.01 | 25 | 152.20 | 28 | 158.59 |
| 17 | 166.97 | 20 | 167.40 | 23 | 159.72 | 26 | 160.49 | 29 | 159.37 |
| 18 | 172.35 | 21 | 169.57 | 24 | 182.22 | 27 | 175.31 | 30 | 183.82 |
| Mean | 167.18 | 163.06 | 166.32 | 162.67 | 167.26 | ||||
| SD | 5.073 | 9.453 | 13.839 | 11.708 | 14.347 | ||||
| Day 3 (Female) | |||||||||
| A # | G1 | A# | G2 | A# | G3 | A# | G4 | A# | G5 |
| 16 | 170.86 | 19 | 163.62 | 22 | 166.71 | 25 | 163.06 | 28 | 170.85 |
| 17 | 176.70 | 20 | 175.93 | 23 | 166.87 | 26 | 172.04 | 29 | 166.27 |
| 18 | 177.69 | 21 | 180.91 | 24 | 180.41 | 27 | 188.42 | 30 | 192.59 |
| Mean | 175.08 | 173.49 | 171.33 | 174.51 | 176.57 | ||||
| SD | 3.691 | 8.900 | 7.864 | 12.859 | 14.061 | ||||
A#= Animal number; G1=Vehicle control: 0 mg/kg/day; G2=Synacinn™: 300 mg/kg/day; G3=Synacinn™: 600 mg/kg/day; G4= Synacinn™: 1000 mg/kg/day; G5= Synacinn™: 2000 mg/kg/day.