Table 17.

Individual animal PCE/E and PCE/NCE ratio at Phase I.

		PCE		NCE		Total E		PCE/E		PCE/NCE
Group	A#	M	F	M	F	M	F	M	F	M	F
G1	1	360	330	198	172	558	502	0.65	0.66	1.82	1.92
	2	342	362	166	152	508	514	0.67	0.70	2.06	2.38
	3	390	324	188	296	578	620	0.67	0.52	2.07	1.09
Mean	364	339	184	207	548	545	0.66	0.63	1.98	1.80
SD	24.2	20.4	16.4	78.0	36.1	64.9	0.012	0.095	0.142	0.654
G2	4	354	360	174	208	528	568	0.67	0.63	2.03	1.73
	5	380	356	220	201	600	557	0.63	0.64	1.73	1.77
	6	364	352	190	196	554	548	0.66	0.64	1.92	1.80
Mean	366	356	195	202	561	558	0.65	0.64	1.89	1.77
SD	13.1	4.0	23.4	6.0	36.5	10.0	0.021	0.006	0.152	0.035
G3	7	358	380	142	172	500	552	0.72	0.69	2.52	2.21
	8	322	328	182	222	504	550	0.64	0.60	1.77	1.48
	9	362	330	160	176	522	506	0.69	0.65	2.26	1.88
Mean	347	346	161	190	509	536	0.68	0.65	2.18	1.86
SD	22.0	29.5	20.0	27.8	11.7	26.0	0.040	0.045	0.381	0.366
G4	10	361	312	162	188	523	500	0.69	0.62	2.23	1.66
	11	396	461	182	228	578	689	0.69	0.67	2.18	2.02
	12	398	340	202	164	600	504	0.66	0.67	1.97	2.07
Mean	385	371	182	193	567	564	0.68	0.65	2.13	1.92
SD	20.8	79.2	20.0	32.3	39.7	108.0	0.017	0.029	0.138	0.224
G5	13	368	337	194	195	562	532	0.65	0.63	1.90	1.73
	14	352	310	152	191	504	501	0.70	0.62	2.32	1.62
	15	394	337	194	167	588	504	0.67	0.67	2.03	2.02
Mean	371	328	180	184	551	512	0.67	0.64	2.08	1.79
SD	21.2	15.6	24.2	15.1	43.0	17.1	0.025	0.026	0.215	0.207

A#= Animal number; M=Male; F= Female; PCE= Polychromatic Erythrocytes; NCE= Normochromatic Erythrocytes; E= Erythrocytes; G1=Vehicle control: 0 mg/kg/day; G2=Synacinn™: 300 mg/kg/day; G3=Synacinn™: 600 mg/kg/day; G4= Synacinn™: 1000 mg/kg/day; G5= Synacinn™: 2000 mg/kg/day.