Table 1.
Demographic and clinical characteristic of the cohort divided by genetic group and CDR®+NACC FTLD global scores. Abbreviations: N/A not applicable, FTD frontotemporal dementia, bvFTD behavioural variant FTD, PPA primary progressive aphasia, NOS not otherwise specified, CBS corticobasal syndrome, PSP progressive supranuclear palsy, AD Alzheimer’s disease, ALS amyotrophic lateral sclerosis.
| Non-carriers |
C9orf72 expansion carriers |
MAPT mutation carriers |
GRN mutation carriers |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CDR®+NACC FTLD global score | 0 | 0.5 | ≥1 | 0 | 0.5 | ≥1 | 0 | 0.5 | ≥1 | |
| N | 298 | 107 | 32 | 63 | 47 | 13 | 20 | 125 | 30 | 43 |
| Age, year | 45.8 (12.5) | 43.9 (11.7) | 49.4 (11.7) | 62.9 (9.2) | 39.3 (10.6) | 47.0 (12.0) | 58.2 (10.1) | 45.5 (12.0) | 52.0 (13.3) | 63.6 (8.2) |
| Sex, male (%) | 125 (41.9%) | 44 (41.1%) | 12 (37.5%) | 41 (65.1%) | 20 (42.6%) | 4 (30.8%) | 13 (65.0%) | 43 (34.4%) | 15 (50%) | 21 (48.8%) |
| Scanners [Siemens Trio/Siemens Skyra/Siemens Prisma/Philips Achieva/GE Discovery MR750] | 59/64/79/94/2 | 32/14/19/42/0 | 4/4/10/14/0 | 8/11/27/16/1 | 11/11/8/16/1 | 1/1/8/3/0 | 6/2/10/2/0 | 39/20/16/45/5 | 5/7/9/8/1 | 11/11/14/7/0 |
| Clinical phenotype | N/A | N/A | N/A | 49 bvFTD, 6 FTD-ALS, 2 ALS, 2 PPA, 1 PSP, 2 Dementia-NOS, 1 Other | N/A | N/A | 16 bvFTD, 1 PPA, 2 Dementia-NOS, 1 PSP | N/A | N/A | 24 bvFTD, 17 PPA, 1 CBS, 1 AD |