Fig. s2.

Heatmap of RNA-seq reporting changes in hepatic genes in the Med13^fl/fland MED13-LKO mice under fed states. A) Absolute of log2foldchange in gene expression for the Med13^fl/fl and MED13-LKO mice under feeding with 30% sucrose or fructose water supplementation compared with fasted liver samples. Genes with |log2foldchange| > 1 and padj (adjusted p value) < 0.05 in the MED13^fl/fl mice were selected as rows of the heatmap, and the intensity of the red color represents the magnitude of fold changes in either the up or down direction. B) Log2foldchange in gene expression for the Med13^fl/fl and MED13-LKO mice under feeding with 30% sucrose or fructose water supplementation compared with fasted liver samples. Genes with |log2foldchange| > 1 and padj (adjusted p value) < 0.05 in the Med13^fl/fl mice were selected as rows of the heatmap, and the intensity of the red color represents the magnitude of fold changes in either the up or down direction. C) Feeding induced and reduced gene populations in the Med13^fl/fl (blue) and MED13-LKO (orange) mice with sucrose or fructose water supplementation. Genes with padj <0.05 were counted. D) Gene ontology analysis of both upregulated and downregulated genes in the MED13-LKO mice compared to the Med13^fl/fl mice under fructose water supplementation. Genes with |log2foldchange| > 1 and padj (adjusted p value) < 0.05 were used as an input list to the DAVID functional annotation tool, and all of the genes detected in the experiment were used as background. Bar graph shows log10(padj) and the numbers beside the bars show the number of input genes in the GO term.