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. 2021 Mar 31;48:101227. doi: 10.1016/j.molmet.2021.101227

Figure 7.

Figure 7

Luciferase reporter assay of ChREBP and FOXO1 transfactors in MED13-LKO mice. Isolated primary hepatocytes from adenovirus (Ad)-GFP (Ad-WT) or Ad-Cre (Ad-KO) transduced Med13fl/fl (WT) or Med13fl/flAlb-Cre (KO) mice were used. A) Luciferase reporter assays for the effects of ChREBP-β on ChoRE activity in either Med13fl/fl (WT and Ad-WT) or Med13-LKO (KO and Ad-KO) as indicated. B) Luciferase reporter assays for the effects of FOXO1 on G6pc promoter activity in indicated cells, either from Med13fl/fl (WT and Ad-WT) or Med13-LKO (KO and Ad-KO). P values were determined by Student's t-test (p < 0.05). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and n = 3. The values above each of the error bars indicate the fold stimulation.