Figure 1.

Differentially expressed genes (DEGs) identified in human BCC and SCC by comparison between tumor and adjacent normal skin. (A) shows principal component analysis (PCA) of BCC (PC2, left) and SCC (PC3, right) (including both tumors and matched adjacent normal skin). (B) and (C) show volcano plots for BCC (B) and SCC (C), where the purple dots represent the DEGs up-regulated and blue dots being those down-regulated. (D) and (E) show gene expression profiles achieved by RNA-seq (blue bars in the left panel) and validated by real-time PCR (brown bars in the right panel) of several DEG examples for BCC (D) and SCC (E).