Table 2.
Biological function of lncRNAs in HCC.
| Biological Function | LncRNA | Target Gene/Pathway | Reference(s) |
|---|---|---|---|
| Promote proliferation, migration, and invasion | HOTAIR | OGFr, miR-122, SETD2 | 90, 91, 92, 93, 94 |
| IHS | ERK- and AKT/GSK-3β | 96 | |
| HOXD-AS1 | SOX4 | 97 | |
| PDPK2P | PDK1/AKT/Caspase 3 | 98 | |
| ATB | autophagy-related protein 5 | 99 | |
| Ftx | PPARγ | 100 | |
| lncCAMTA1 | CAMTA1 | 101 | |
| SNHG15 | miR-490-3p/histone deacetylase 2 axis | 102 | |
| RNA LINC00908 | Sox-4 | 103 | |
| MCM3AP-AS1 | miR-194-5p/FOXA1 axis | 104 | |
| Suppress proliferation and invasion | GAS8-AS1 | GAS8 | 105 |
| SVUGP2 | MMP2 and 9 | 106 | |
| uc.134 | LATS1 | 107 | |
| TCONS_00006195 | ENO1 | 108 | |
| EPB41L4A-AS2 | miR-301a-5p/FOXL1 | 109 | |
| FENDRR | miR-423-5p | 110 | |
| SchLAH | – | 111 | |
| GAS5 | miR-182/ANGPTL1 | 112 | |
| MIR31HG | microRNA-575 | 113 | |
| MIR22HG | miR-10a-5p/NCOR2 | 114 | |
| Estimate prognosis and efficacy | HOTAIR | – | 92 |
| MIR22HG, CTC-297N7.9, CTD-2139B15.2, RP11-589N15.2, RP11-343N15.5, and RP11-479G22.8 | – | 115 | |
| MALAT1, HOTAIR, MDIG | Caspase-8/LSD1/H3K9me3/ | 116 | |
| miR503HG | HNRNPA2B1/NF-κB | 117 | |
| RP11-466I1.1 | – | 118 | |
| Act as potential biomarkers | PVT1, uc002mbe.2 | – | 119 |
| UCA1 | – | 120 | |
| LRB1 | – | 121 | |
| RP11-486O12.2, RP11-863K10.7, LINC01093 and RP11-273G15.2 | – | 122 | |
| ELMO1-AS1 | – | 123 |
Note: References 91–105 discuss the promotion of cancer cell proliferation and invasion, References 106–115 discuss the suppression of cancer cell proliferation and invasion, References 93 and 116–119 discuss the estimation of prognosis, and References 120–124 discuss the efficacy or potential biomarkers.