Table 2.
Comparison of clinical data between small and large PA lesion groups (outcome cohort)
| Variables | S-PAL group (n = 26) | n | L-PAL group (n = 87) | n | p values | Statistics |
|---|---|---|---|---|---|---|
| CT, tumor size (mm, threshold: 5 mm) | 10.0 (2.5–17.6) | 26 | 15.0 (10.0–17.7) | 87 | 0.097 | MW-U |
| Age (year) | 50.0 (43.0–63.0) | 27 | 50.0 (41.0–61.0) | 87 | 0.73 | MW-U |
| Sex (male vs. female) | 14 (51.9%) vs 13 (48.1%) | 27 | 44 (50.6%) vs 43 (49.4%) | 87 | 1.0 | Fisher |
| Side of adrenalectomy (left vs. right) | 17 (63.0%) vs 10 (37.0%) | 27 | 46 (52.9%) vs 41 (47.1%) | 87 | 0.39 | Fisher |
| Body mass index (kg/m2) | 24.4 (22.2–27.7) | 27 | 23.1 (20.3–27.0) | 87 | 0.29 | MW-U |
| eGFR (mL/min/1.73 m2) | 83.4 (74.3–96.5) | 25 | 80.7 (68.1–97.5) | 86 | 0.53 | MW-U |
| Systolic blood pressure (mmHg) | 138.8 ± 17.8 | 27 | 142.1 ± 18.3 | 85 | 0.41 | uTT |
| Diastolic blood pressure (mmHg) | 87.4 ± 12.7 | 27 | 86.7 ± 12.9 | 85 | 0.80 | uTT |
| Intensity of antihypertensives | 1.33 (1.00–2.17) | 27 | 2.00 (1.00–2.50) | 87 | 0.012 | MW-U |
| Lateralized ratio (LR) in AVS | 5.24 (3.16–8.23) | 20 | 14.59 (4.79–31.86) | 60 | <0.001 | MW-U |
| CYP11B2 positivity | 3.26 ± 3.97 | 27 | 33.1 ± 12.8 | 87 | <0.001 | uTT |
| Serum K level (mEq/L) | 3.61 ± 0.46 | 27 | 2.86 ± 0.58 | 86 | <0.001 | uTT |
| PAC (pg/mL) | 164.0 (139.0–217.0) | 27 | 320.0 (232.8–517.0) | 86 | <0.001 | MW-U |
| PRA (ng/mL/hr) | 0.200 (0.100–0.300) | 27 | 0.200 (0.100–0.300) | 86 | 0.51 | MW-U |
When a tumor was not detected on CT and the size of tumor was shorter than 5 mm, the tumor size in statistical analyses was set at 2.5 mm
BP blood pressure, eGFR estimated glomerular filtration rate, PAC plasma aldosterone concentration, PRA plasma renin activity, ARR aldosterone-renin ratio = PAC/PRA, AVS adrenal venous sampling, MW-U the Mann–Whitney U test, the unpaired t-test: uTT, S-PAL group small PA lesion group, L-PAL group large PA lesion group